Penny is worried with how damaged her friendship with the guys will be in the aftermath of her sleeping with Raj while Sheldon becomes the leader of the paintball team.
A fight between Sheldon and Penny leaves Amy caught in the middle, while Leonard tries to spice up his long-distance relationship with Priya.
Leonard and Amy get to know each other better, while Howard and Bernadette spend the weekend with Mrs. Wolowitz.
Penny plays Matchmaker for Raj, which results in him finding a girl he is comfortable talking to.
Sheldon and Leonard get invited to a party at Wil Wheaton's house, and Howard gets an out-of-this-world opportunity.
Sheldon's mother, Mary Cooper, comes to visit, but Sheldon is annoyed that she spends time with the rest of the gang instead of catering to his every demand.
A cute comic book artist puts Leonard and Priya’s relationship to the test, while Sheldon tries to scare the guys for Halloween.
Amy becomes heartbroken when she discovers that Penny and Bernadette went wedding dress shopping without her.
Leonard and Penny try hanging out as friends on a 'non-date', but end up purposely ruining each others chances with perspective dates. Meanwhile, Sheldon enlists the help of Bernadette and Amy to overcome his fear of birds.
Sheldon becomes jealous when Stuart asks Amy for a date.
Leonard must face his fears after being contacted by his high school tormentor.
Sheldon gets in trouble with Amy when he isn't impressed by her recent accomplishment, and Howard must come to grips with Bernadette's dislike of children.
Leonard, having broken up with Priya, asks Penny out to a spur-of the-moment romantic dinner for two.
Leonard and Penny deal with the idea of starting a relationship again and Raj finally finds a 'woman' he can talk to without being drunk, in the form of Siri on his new phone.
Sheldon's selfish demands force Leonard to reconsider their friendship. Meanwhile, Wolowitz tries to pick his astronaut nickname.
When Sheldon is forced to take his vacation, he goes to work with Amy in her neurobiology lab.
Penny is horrified when Amy gives her a gift: a huge, quite horrible painting of the two of them. With no good way to avoid displaying it, she only hangs it up when Amy is over.
Sheldon becomes agitated when his regular barber is out sick. Astronaut training causes Howard to reconsider wanting to go into space.
Sheldon must choose between joining Amy at her aunt's birthday party or playing videogames all weekend with the guys.
Penny buys Leonard and Sheldon “Star Trek” collectibles as a thank-you, leading Sheldon to be haunted by Mr. Spock. Meanwhile, Raj decides he has met the 'Future Mrs. Koothrappali' after his parents set him up on a date.
When Wolowitz gets to work with Stephen Hawking, Sheldon is willing to do anything to meet his hero.
After the guys throw Howard a bachelor party, Bernadette reconsiders marrying him after learning about his sexual history.
When NASA moves up Howard's mission, he must face his fears and Bernadette's dad, thus putting the wedding plans in jeopardy.
The fifth season ends with Howard and Bernadette deciding to get married before his NASA mission, causing the gang to scurry into overdrive in an effort to stage the wedding.