Max and Sharpe wake up to a new, more personal dynamic. Iggy calls upon an old contact to help with an explosive situation. Bloom begins a tricky dynamic with her new ED residents and Reynolds finds himself in an awkward position with Dr. Baptiste and Dr. Lyn Malvo.

Max and Sharpe go public with their relationship at the hospital. The team struggles to keep a handle on an overcrowded and understaffed ICU and everyone must pitch in. Iggy's overly critical feedback alienates his residents.

Max advises a young student at a science fair but encounters legal complications with her brilliant invention. Bloom encourages Dr. Shinwari to be more aggressive in the ED. Iggy gets a lesson in humility. Brantley has a surprise for the staff.

Max struggles with a new fiscal reality at the hospital. Dr. Sharpe's on a mission to provide follow-up cancer screenings for patients before it's too late. Bloom grapples with Dr. Shinwari's new overnight schedule. Reynolds has an interesting discussion with Dr. Malvo.

Dr. Fuentes continues her quest to remake the hospital in her vision. Max goes the extra mile to help a patient in need. Dr. Sharpe and Iggy find themselves at odds over a very serious issue. Reynolds discovers the importance of personal obligations.

Dr. Reynolds and Dr. Malvo have a heart-to-heart with Dr. Baptiste. Max learns a little more about Sharpe when someone from her past resurfaces. Iggy plays referee between two young patients and their families. Dr. Wilder reconsiders Max's offer to join the staff.

Max and Bloom are shocked when a deadly ambulance crash reveals a dangerous plan. Dr. Fuentes pressures Iggy to take on patients. Sharpe realises her own cost-cutting has adversely affected her department. Reynolds, Baptiste and Malvo strive to reach an accord.

Max is faced with a wrenching decision when New Amsterdam falls prey to a massive ransomware attack.

Max takes drastic measures to help several undocumented immigrants after a fire destroys the church where they had sought refuge. Sharpe and Malvo assist a patient with a life-threatening condition. Dr. Reynolds is conflicted about his new position.

As Max and Dr. Sharpe prepare to depart for London, a deadly superbug hits the hospital and draws them back in. Leyla confronts Bloom about the secret she has been hiding. Iggy digs deep to help two grieving parents confront the reality that their son is gone.

Max and Helen settle happily into their new life in London. Dr. Fuentes takes over as medical director with disastrous effects. Bloom helps a patient who thinks he's cursed. Iggy develops a plan to get his psych patients gainfully employed.

Helen takes the reins at NHS Hampstead Hospital while Max gets creative to help a patient. Reynolds reaches a decision about Dr. Malvo. Iggy and Bloom help their patients understand the underlying cause of their stress. Dr. Wilder employs more unconventional techniques.

Max and Helen adjust to sharing their lives and their problems, including the challenge of Helen's mother. Bloom and Reynolds treat a family after their horrific car accident lands them in the ED. Iggy and Trevor reach a new understanding in their business relationship.

As the team gathers to mourn the loss of someone dear, Max and Helen realise the extent to which New Amsterdam has changed since they left. Bloom struggles with a big decision. Reynolds decides to take his concerns for his patients to a new level.

Max formulates a bold plan to help New Amsterdam before it's too late. Reynolds and Dr. Fuentes fight over how to handle a risky surgery. Dr. Wilder asks Dr. Castries for help with a patient with terminal cancer. Iggy helps a father and son deal with a shared trauma.

As the team gathers to mourn the loss of someone dear, Max and Helen realise the extent to which New Amsterdam has changed since they left. Bloom struggles with a big decision while Reynolds decides to take his concerns for his patients to a new level.

The New Amsterdam team continues to deal with the consequences of their big night out. Max and Helen discuss options for their future. Martin finally learns Iggy's secret. Bloom helps Leyla avoid a life-changing situation.

Max orchestrates a plan to get Dr. Fuentes terminated from New Amsterdam once and for all. Helen confronts her medical complication. Iggy helps two patients deal with a breakup, which forces him to consider his own marriage.

Max discovers a fatal flaw in Dr. Fuentes' scheme to purchase the UMI medical clinic, which could be her ultimate undoing. Bloom treats two students for life-threatening injuries and uncovers a dangerous situation. Reynolds helps two siblings confront a family crisis.

Max discovers the extent to which Dr. Fuentes' cuts are severely damaging New Amsterdam and decides it's now or never. Iggy takes an unconventional approach to reach a young patient in need. Reynolds and Wilder perform a risky, life-saving surgery on unborn twins.

When an elder care facility shuts down, New Amsterdam is forced to intake many new patients. Max struggles with his decision to head back to London. Reynolds takes his personal frustrations out on his department with near disastrous results.

As a monster hurricane approaches New York, Bloom and the team scramble to put measures in place. Max and Helen make plans for an intimate New York wedding as she returns from London. Iggy and Martin reach a crossroads. Reynolds finally makes contact with his father.