Having invested in a restaurant with Ted Danson, Larry shops for waiters' uniforms in lieu of attending his dentist's dinner party. Following an emergency visit to his dentist (who learns why Larry skipped the party), Larry is left with two abnormally large front teeth.
After a food allergy at Larry's restaurant, Deborah refuses to take medicine to clear up the hives on her face. Richard will not be seen with her at the Emmy Awards that night, so he and Larry concoct a plan to bake a batch of Benadryl-laced brownies for Deborah to eat.
When Randy quits, Ted suggests they audition his personal chef but Larry rejects the candidate. Larry accuses Cheryl of having a crush on a tennis-playing cast member; a couple refuse Larry's wedding gift; and a saleswoman becomes convinced that Larry is stalking her.
Larry, Cheryl, Jeff and Susie encounter a "nanny from hell" whose reign of terror is thwarted by ten sponge cakes. Larry commits a "penis faux pas" after a pool party, and Richard Lewis seeks immortality from Bartlett's Quotations.
A rumoured threat of a terrorist attack undermines a benefit performance by Alanis Morissette at the home of one of Larry's friends. Meanwhile, Larry can't help snubbing Mindy Reiser during a series of encounters at a restaurant and the perfume shop where she works.
Larry's mother dies while he's shooting a film in New York City, but he doesn't find out until he returns to LA two days after the funeral. Meanwhile, Richard Lewis accuses Larry of taking back his meditation mantra, and Larry plots to relocate his mother's body.
Jeff's return home is ruined by his allergy to the family's corpse-sniffing German Shepherd but his daughter refuses to give away the dog. Concerned about his agent's welfare, Larry figures out a way to give the pooch to the Braudys, who are looking for just such a dog.
Larry is accused of betraying the confidences of Wanda's boyfriend, a rapper he met at a party. Later, Larry alienates Jeff's wife Susie by passing on her house-tour offer, then runs into problems trying to replace a sports jacket Cheryl threw out.
Larry proves himself an unskilled Christmas tipper. After offending his housekeeper, Larry makes amends with her at the expense of his wife. Later, Larry attempts to reconcile with Cheryl's family after ruining their nativity scene.
Larry figures out a way to fire a chef, and alienate an important restaurant critic, in the days before his new restaurant is scheduled to open. As Susie stews over a misunderstanding with Larry and Cheryl, the Davids spend some quality time at the car wash.