Brilliant physicist roommates Leonard and Sheldon meet their new neighbor Penny, who begins by showing them that as much as they know about science, they know little about actual living.

Leonard volunteers to sign for a package in an attempt to make a good impression on Penny, but when he enlists Sheldon for help, his attempt at chivalry goes terribly awry.

Leonard asks a woman out after he finds out that Penny is seeing someone.

Getting fired forces Sheldon to explore what life has to offer outside physics, leaving Leonard to take drastic action to snap his friend out of his funk.

Sensing that he's wasting his time on Penny, Leonard ends up making a connection with Leslie.

Penny hosts a Hallowe'en party, putting Leonard, Sheldon, Wolowitz, and Koothrappali through a new test of their social skills.

With Wolowitz AWOL with one of her friends, Penny's recruited to fill in for him on the guys' Halo team.

Raj's parents set him up on a blind date, but just when he discovers he can talk to her, she shows interest in Sheldon.

When they're invited to present at a physics conference, Sheldon's reluctance to share the credit leads to a tiff between him and Leonard. Penny's intervention only exacerbates the situation.

Leonard and Sheldon each lie to avoid seeing Penny's concert, but Sheldon's is a bit too complicated for his own good.

With his friends knowing how sour he acts when he’s sick, Sheldon is nursed by Penny, who hasn't got a clue what she's in for.

With Sheldon rattled over meeting Dennis, a 15-year-old physicist who's smarter than he, Leonard helps him look for a way to debunk Dennis's research.

Sheldon finds himself booted from the gang's Physics Bowl team and replaced with Leslie, so he forms his own team hoping to prove he's superior.

When delivery of another collectible leads to Penny's lashing out at Leonard, he decides it's time to give up his habit, much to his friends' protestation.

The rest of the gang fall for Sheldon's twin sister and Leonard's plan to win her heart is derailed when Sheldon declares he'll be the one to decide who can date her.

Penny wants to throw a surprise party for Leonard, but Sheldon's indulgence at an electronics store throws her off-track.

Penny's break-up spurs Leonard to summon the courage to ask her out. Both go to Sheldon for advice on their upcoming date.

Penny's first date with Leonard goes awry and she finds Sheldon to be an unwilling confidant.

A jealous Leonard reacts to Penny's new guy by rebounding with Leslie.

Sheldon creates a monster when he introduces Penny to online gaming.

Raj gets an inflated ego and makes a play for Penny after being referenced in a magazine article.

Leonard and his friends stage an intervention to force Sheldon to face his fear of driving.

Sheldon and the gang are confused when a young grad student is attracted to him.

When Sheldon bans Penny from the apartment for numerous minor infractions, she decides to retaliate.

Leonard inadvertently steals away the new woman Wolowitz thinks is the love of his life.

Sheldon is thrilled when Leonard starts dating a woman who meets Sheldon's stringent standards.

Leonard asks Penny for advice when his new relationship starts moving too fast.

Penny starts dating Leonard's handsome colleague; Leonard and his friends are tortured by Sheldon's obsession with gift-giving etiquette.

Penny's criticism of Wolowitz's romantic life pushes him into depression and he goes AWOL for a fighting robot battle the rest of guys are depending on him for.

Sheldon creates a scientific procedure for making friends.

Sheldon's solution to Penny's financial difficulty leads to a confrontation between Leonard and Penny's ex-boyfriend.

Leonard and Penny are drawn together after a disastrous visit from Leonard's mother.

A paintball game leads to a fight between Sheldon and Penny and romance for Leslie and Wolowitz.

Leonard, Sheldon and Wolowitz are ecstatic to learn that a famous science-fiction actress (Summer Glau) is on board the train they are taking to San Francisco.

Penny's home business turns into a complete nightmare when Sheldon takes over.

Penny squares off with a new beautiful female neighbor who may become the building's 'new Penny'.

A fellow comic book enthusiast's hitting on Penny leads to Leonard and Howard going to a bar's Ladies' Night.

Leonard and Koothrappali escort a heartbroken Wolowitz to Las Vegas. Sheldon becomes locked out of his apartment so must stay with Penny.

Penny's second date with Stuart sees her making a comment that gives Leonard new hope for a relationship with her. Wolowitz realizes there's a crucial error in a NASA project he's working on.

The guys' plan to work over the summer at the North Pole makes Penny revaluate her feelings for Leonard.

Leonard and Amy take a road trip.

Howard takes a class that Sheldon's teaching.

Howard is invited by NASA to throw the first pitch at a game.

Penny wonders why Raj's girlfriend doesn't like her.

The guys unsuccessfully try to invent "the next big thing".