The doctors take a gamble in Sin City, helping a young woman whose autoimmune disease may have triggered her deformed breasts.

The doctors meet a war veteran who was struck by lightning, leaving her breasts and body disfigured, and a woman who has a misplaced toe on each foot.

The doctors see a man whose infected chest implant is threatening his life, while twins with matching cleft deformities want to look more identical.

The doctors meet with a man whose nasal syndrome has him tired of facing the public and a woman who was born with a conjoined twin at the butt.

The doctors meet a woman with severely deformed breasts. Later, the doctor becomes the patient when Dr. Nassif has a serious medical condition.

The doctors meet a young mother whose underlying breast issues are getting harder to deal with and a woman with nasal complications.

The doctors help a woman with a collapsed nose, a college student with an extremely oversized breast, and check up on Tiffany Pollard.

In the season finale, the doctors visit a young mother in Detroit who breasts never developed normal tissue due to Tubular Breast Deformation. In Atlanta they consult with a woman who has a tumor that causes her to have overgrown tissue in her mouth.