Leonard and Sheldon are brilliant physicists, the kind of "beautiful minds" that understand how the universe works. But none of that genius helps them interact with people, especially women. All this begins to change when free-spirited beauty Penny moves in next door.
Brilliant physicist roommates Leonard and Sheldon meet their new neighbor Penny, who begins by showing them that as much as they know about science, they know little about actual living.
Leonard volunteers to sign for a package in an attempt to make a good impression on Penny, but when he enlists Sheldon for help, his attempt at chivalry goes terribly awry.
Leonard asks a woman out after he finds out that Penny is seeing someone.
Getting fired forces Sheldon to explore what life has to offer outside physics, leaving Leonard to take drastic action to snap his friend out of his funk.
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Sensing that he's wasting his time on Penny, Leonard ends up making a connection with Leslie.
Penny hosts a Hallowe'en party, putting Leonard, Sheldon, Wolowitz, and Koothrappali through a new test of their social skills.
With Wolowitz AWOL with one of her friends, Penny's recruited to fill in for him on the guys' Halo team.
Raj's parents set him up on a blind date, but just when he discovers he can talk to her, she shows interest in Sheldon.
When they're invited to present at a physics conference, Sheldon's reluctance to share the credit leads to a tiff between him and Leonard. Penny's intervention only exacerbates the situation.
Leonard and Sheldon each lie to avoid seeing Penny's concert, but Sheldon's is a bit too complicated for his own good.
With his friends knowing how sour he acts when he’s sick, Sheldon is nursed by Penny, who hasn't got a clue what she's in for.
With Sheldon rattled over meeting Dennis, a 15-year-old physicist who's smarter than he, Leonard helps him look for a way to debunk Dennis's research.
Sheldon finds himself booted from the gang's Physics Bowl team and replaced with Leslie, so he forms his own team hoping to prove he's superior.
When delivery of another collectible leads to Penny's lashing out at Leonard, he decides it's time to give up his habit, much to his friends' protestation.
The rest of the gang fall for Sheldon's twin sister and Leonard's plan to win her heart is derailed when Sheldon declares he'll be the one to decide who can date her.
Penny wants to throw a surprise party for Leonard, but Sheldon's indulgence at an electronics store throws her off-track.
Penny's break-up spurs Leonard to summon the courage to ask her out. Both go to Sheldon for advice on their upcoming date.