Explorer Sir Malcolm Murray, American gunslinger Ethan Chandler, scientist Victor Frankenstein and medium Vanessa Ives unite to combat supernatural threats in Victorian London.
Feeling abandoned and alienated by her faith, Vanessa seeks the help of Dr. Seward, a therapist who has an unconventional way of treatment. Now a prisoner under the watchful eye of Inspector Rusk, Ethan is on a train speeding through the desert of the American West.
Lily and Dorian rescue a young woman; Sir Malcolm continues on his journey with the enigmatic Kaetenay; Ethan gets some unexpected help from Hecate.
Ethan and Hecate race across the desert with Sir Malcolm and Kaetenay hot on his trail. The Creature returns to London desperately trying to piece his former life back together. After Dr. Jekyll and Dr. Frankenstein's plan fails, they come up with a new strategy.
Vanessa convinces Dr. Seward to use hypnosis to take her back in time, and discovers what really happened to her during her time at the Banning Institute.
Hecate and Ethan struggle to survive the harsh wasteland of the New Mexico desert. Kaetenay reveals to Sir Malcolm the truth behind his connection to Ethan. Back in London, Frankenstein's addition to Jekyll's formula is a success.
Vanessa turns to her old friend Ferdinand Lyle for help. Lyle introduces her to Catriona Hartdegen, a new ally. Lily, Dorian and Justine put their plan in motion. Ethan, Sir Malcolm and Hecate arrive at Jarod Talbot's ranch.
Kaetenay has a vision of impending doom; Frankenstein and Jekyll get help from an unlikely foe; the Creature finally gains courage. With the help of Catriona, Vanessa learns an awful truth.
Ethan, Sir Malcolm and Kaetenay return to London; Dr. Seward discovers Renfield's secret. Ethan, meanwhile, heads out in search of Dr. Frankenstein, and Lily reveals a heartbreaking story from Brona Croft's past.
London 1891. As the police investigate a series of gruesome murders, renowned explorer Sir Malcolm Murray and the strangely beautiful Vanessa Ives know there's something darker at play.
In pursuit of answers, Vanessa and Sir Malcolm attend a party at Egyptologist Sir Ferdinand Lyle's home where they encounter the mysteriously beautiful Dorian Gray. The party takes a turn, however, when renowned medium Madame Kali hosts a séance.
Dr. Frankenstein is confronted by the consequences of his past. Vanessa has a vision of Mina, which leads her, Sir Malcolm, Ethan and Sembene to a strange discovery at the London Zoo.
Vanessa's infatuation with Dorian Gray continues to grow. Professor Abraham Van Helsing is hired to work with Dr. Frankenstein, and Fenton draws his master to Sir Malcolm's mansion.
Vanessa recalls her past and the events that ultimately lead to Mina's disappearance.
Vanessa's latest vision leads Sir Malcolm, Ethan and Sembene to explore a plague ship in search of Mina, and Van Helsing reveals to Dr. Frankenstein more details about the creature that has taken her.
Sir Malcolm, Ethan and Sembene must deal with the aftermath of Vanessa's night of passion with Dorian when she is possessed by the demon that haunts them... and who has ties to the Master who controls Mina.
After a vision of the Grand Guignol, Vanessa, Sir Malcolm, Ethan, Dr. Frankenstein and Sembene explore an empty theatre - only to be confronted by their worst nightmares.
Vanessa is barraged by an onslaught of disturbing images. Ethan decides to leave London because of the massacre. Pressured by the Creature, Dr. Frankenstein works to bring Brona back to life. Sir Malcolm returns to London to discover that a new evil is hunting Vanessa.
Vanessa seeks solace from Sir Malcolm; Inspector Rusk searches for the sole survivor of the massacre; Dr. Frankenstein gives the re-born Brona a new identity.
In a flashback, Vanessa meets The Cut-Wife, who teaches her how to harness her powers. Isolated at her lonely cottage on the moors, the Cut-Wife quickly realises the extent of Vanessa's powers and warns her of the danger that lies ahead and the evil that pursues her.
Lyle reveals the Verbis Diablo relics tell a very dark and disturbing story. Rusk interviews the survivor of the Mariner's Inn massacre. Back at Sir Malcolm's mansion, Vanessa, Ethan, Sir Malcolm, Sembene and Lyle carry on their evening as something evil lurks within.
Hecate returns to her mother with a gift; Evelyn works on a new totem; the mansion is attacked; the Creature grows impatient with Frankenstein; Rusk interrogates Ethan; Vanessa and the Creature's friendship deepens; Angelique is humiliated while out with Dorian.
Vanessa and Ethan give Sir Malcolm tragic news; Lavinia Putney is disturbed by an encounter with the Creature; Roper hunts down Ethan; Dorian hosts a lavish ball in Angelique's honour; a glorious night turns to horror for Vanessa.
Not feeling safe in London, Vanessa and Ethan flee to the Cut-Wife's cottage on the moors. There they settle into domestic life, until a figure from her dark past resurfaces. Back in London, Lyle and Frankenstein uncover more disturbing information from the relics.
The Creature unleashes his rage on Frankenstein over Lily. Inspector Rusk discovers Sir Malcolm's connection to Ethan Chandler. Malcolm goes to confront Evelyn but quickly finds himself assaulted by another one of her deadly enchantments.
Back in London, Vanessa and Ethan learn that Sir Malcolm is in danger. Desperate to save him, Vanessa goes alone to battle Evelyn. Ethan heads out to Evelyn's mansion with Frankenstein, Sembene and Lyle.
Vanessa must rely on her profound strength to defeat the Demon. Ethan leaves a tragic trail of blood in his wake. Sir Malcolm and Frankenstein must confront ghosts from their past while Lyle helps to rescue his friends. The Creature tries to escape the Putney's.
