The special Federal Bureau of Investigation Missing Persons Squad's sole responsibility is to find missing people by applying advanced psychological profiling to reveal the victims' lives.

Jack and his team search for an 11-year-old boy, Gabe, who disappears from a subway station en route to Yankee Stadium for what was to be his birthday celebration.

As a couple cross to their car after a day of shopping, Duncan realizes that he needs to go back into the store to retrieve his credit card. After Duncan walks away, his wife's car speeds off, leaving a bystander injured.

The agents' job is harder than usual because they must find a woman, who changes her appearance to suit whatever modeling or acting job she is seeking at the time.

Jack and his squad search for a young man, 17-year-old, who was last seen by the charismatic headmaster of Spalding Academy.

Jack and the team search for a New York businessman, who disappears after he checks in for a routine airline flight home.

Jack and his squad search for a toddler, Abby, who was snatched from a park playground while playing with another child.

Jack and the team search for a teenager, William Hope, who goes missing in a very bad neighborhood after a confrontation with a local bully.

The team investigates the disappearance of Anwar Samir, a Saudi Arabian medical intern who became upset when his boss refused to write a letter of recommendation for him, and his girlfriend declined his marriage proposal.

Jack and the team investigate a father and his daughter, who disappear during their regular morning routine.

The citizens of a small Long Island town are shocked when 13-year-old Annie Miller disappears on her way to school.

Jack and the team search for a pregnant woman, Kathy Dobson, who disappeared from a hospital before being told that she has serious complications.

Jack is distraught and defensive when Chet Collins, whose son has been missing for 6 years, decides to search for him on his own because he thinks Jack has given up hope of finding him.

Jack and the team search for an airline stewardess, Linda Schmidt, who disappeared on her way to the airport.

Jack and his squad investigate a bride, Audrey Rose, who disappears from her wedding celebration.

Jack and his squad search for a teenage girl, Clare Metcalf, who disappears from a mental hospital after she suffers an extreme psychotic episode

Jack and the team search for a recently retired U.S. Army officer who disappears following a dinner in his honor given by former members of his Vietnam platoon.

Jack and the team search for a tenacious television reporter after she disappears in the middle of a dangerous, high-profile investigation.

Jack's squad looks for a young, idealistic and dedicated schoolteacher, who disappeared after teaching a night class in the Bronx.

Jack and the team search for a boxer, Dante Jones, who vanishes before a much anticipated fight at New York's Madison Square Garden.

Jack finds himself at the center of an investigation into how missing persons cases have been handled, including such controversial cases as that of Graham Spaulding' the accused pedophile now on trial.

Jack and his team search for an office worker, Sydney Harrison, who disappeared from her building.

Jack's squad must determine the best course of action when Samantha is shot and possibly critically injured in a hostage situation.

Martin and Danny attempt to dodge a hail of bullets as a mercenary and his cronies try to kill their true target.

The team investigates if 15-year-old whiz kid Ryan Wallace is missing of his own accord in order to execute his elaborate plan to bomb his high school.

The team's newest member, FBI rookie Elena Delgado, formerly of the NYPD, encounters a learning curve as she attempts to help search for missing 20-year-old Dina Kingston.

When the backpack and ID of missing college coed Skye Petersen are suddenly dropped off at a thrift store seven years after, Jack determine she was murdered by her married professor with whom she'd just ended an affair, the team decides to reopen the case.

The team searches for 25-year-old Korean-American Wendy Kim, who vanishes after a fight with her new boyfriend during her night shift at her parents' deli.

Jack and Danny head to Mexico to find a wealthy American vacationer who was abducted at gunpoint in front of his new wife, Lydia Costin.

Jack and the team search for a man, Bill Shields, who reportedly let his marriage and career slip away after his teenaged daughter succumbed to leukemia.

Susan and Larry Hopkins desperately call the authorities when they realize their son, Shawn, has missed his curfew.

The team searches for Jack's friend Max Cassidy, a longtime FBI agent who disappears after leaving an emotional message on the answering machine of his wife.

Samantha investigates the case of a woman with amnesia who may not only be a missing person but a murderer.

A dedicated paramedic disappears from a hospital moments after successfully treating a young thug who was wounded in a shootout.

When a therapist vanishes, the team suspects that one of her former patients may have been involved.

While searching for a missing middle school teacher, the team begins to suspect that she may be having an inappropriate relationship with a 14-year-old student who is also nowhere to be found.

When an ex-Marine, Andy Reynolds, disappears, Jack learns that Andy was accused of rape, dishonorably discharged and imprisoned in Japan for five years before returning to the U.S.

While investigating the disappearance of Leah Robinson, the team begins to suspect that she may not be as innocent as her husband and minister think she is.

The team members attempt to recover a 5-year-old boy, Ethan Heller, who was in the back seat of his family's SUV when it was apparently carjacked.

The team members search for Rachel, an agoraphobic advice columnist who had not left her apartment in 2 years.

After briefly looking for an 18-year-old, the team members realize that the real missing person is 15-year-old Matt Jameson, who was impersonating his former basketball league pal in order to work.

The team members search for a pregnant, HIV-positive woman, Megan, who vanished moments after she and her husband saw the ultrasound of their healthy late-term fetus.

The team searches for Breck Mulligan, a wealthy young man who disappeared from the inner city shelter for indigent women where he had volunteered as part of his sentence for drug possession.

Jack and the team work on the case of a young ice dancer, Kelly McMurphy, who has disappeared.

As the team members search for a recent widower, Ted, and his two teenaged kids, they attempt to determine who is responsible for the gunfire that left the missing family's living room splattered with blood.

When a white girl and a black boy coincidentally vanish on the same night, Jack attempts to counteract Vivian's prediction that the media and FBI will focus more on the white girl's case.

While investigating the disappearance of a former assistant district attorney, Jack talks to her boyfriend, Alan Davis.

When a school bus full of students goes missing during its morning run in a wealthy district, Jack and the team suspect two troublemaking students with a rich, neglectful father.

Jack and the team try to find a priest, Father Henry Stephens, who disappears from his church shortly after learning that he needs a liver transplant to survive.

Whitney Ridder, a beautiful young woman who seems to have everything, disappears from her wealthy fiancé's home during the middle of a dinner party.

Jack and the team search for a brilliant but complicated 14-year-old Russian violinist, Natasha Tzetcovich, who disappeared after a rehearsal for an important concert appearance.

Twelve years ago, Jack worked a serial killer case in which five women were murdered. Now, Jack and the team search for a missing woman whose description is remarkably similar to the five murder victims from long ago.

Jack and his team search for a teenage boy, Ethan Sawyer, after he disappears from his home.

An unidentified young Hispanic boy is abducted from a Spanish Harlem street. Jack and the team are completely baffled when no family members come forward to look for the child.

Jack and the team search for a dedicated and respected firefighter who disappeared after rescuing two fellow firemen from a building engulfed in flames.

Jack and his squad search for a driven neurosurgeon, who disappeared after a nighttime jog in the city with her ex-husband, Dr. Evan Mayhew.

When Luke disappears after an uplifting speech at his high school reunion, Jack and the team find Luke's blood at the location of his disappearance.

Jack and the team look for a paparazzo after he vanishes from a celebrity shoot, and his camera is found covered in blood.

Jack and the team search for Joe Gibson, who disappeared after a chase and gunfight with unidentified figures.

Renowned motivational speaker Will Sterling is kidnapped at his mansion minutes before his limousine arrives to take him to the airport for an out-of-town seminar.

Jesse Prince, a female ex-cop turned bounty hunter, vanishes after being shot at in front of a fugitive's home.

Jack and the team try to find Eric Miller, a 12-year-old, who was last seen in the boys' bathroom at his school.

Four years ago, a young woman, Jessica Raab, went missing. Vivian's weekly fingerprint search on the unidentified print found on Jessica's door finally results in a match.

The team searches for an injured U.S. soldier, who recently returned from war.

George Stanley argues with his wife at her hair salon, leaves to deposit the day's earnings and never returns.

While searching for Julie Cochran, a Manhattan-based woman who disappeared on the morning she was scheduled to leave town, the team soon suspects her live-in boyfriend, Greg Knowles.

After Martin's Aunt Bonnie, a feeble cancer patient and nurse, vanishes for several hours, her concerned husband and adult daughters summon Martin to help find her.

The team searches for Mark Wilson, who disappeared while trying to prove the innocence of his death-row inmate son, Ricky, scheduled to die in two days.

The team searches for college football coach Jim Cooper, who goes missing after being terminated for his team's unusually dismal season performance.

Jack and his team try to determine if foul play was involved in the 1991 adoption of 16-year-old Serene Barnes after the teen shows up at the FBI offices claiming she was kidnapped as a young child.

On Jack's last case before he moves to Chicago, the team searches for a billionaire's estranged wife and their two children after the yacht they were last seen boarding is soon found adrift in New York Harbor--with only its dead captain aboard.

Jack and the squad search for a celebrity couple's Sudanese 2-year-old adopted son, who is kidnapped from his home.

The team members investigate when a man and his 18-year-old daughter mysteriously go missing.

The team investigates the disappearance of a grieving woman and tries to determine whether or not she went missing while trying to rescue her son in Central America.

The team members search for a woman who disappeared after the police killed her boyfriend.

The team members try to locate a woman who disappeared in the aftermath of an office shooting.

The FBI team and Gil Grissom search for a pattern that will help them capture a suspected serial killer.

The team members search for a male college student who vanished after making provocative, racist statements about African Americans to an acquaintance during a classroom discussion.

When an ultimate fighter disappears after winning a match, the team discovers he knew a lot of people that could have been responsible for his abduction.

When an ex-con who has recently been released from prison goes missing, the team questions whether her past mistakes, including embezzling money from former clients, may have come back to haunt her.

A college student and former child prodigy receives a death threat and subsequently disappears while working in a mall as a department store Santa.

The team attempts to locate Scott Lucas, a private investigator who has gone missing while doing undercover surveillance.

The team investigates the case of a woman who vanished from the veteran's hospital where she was doing community service work.

Jack tries to find a doctor who has performed illegal abortions on women forced to work as prostitutes in a human trafficking ring headed by Franklin Romar.

While Jack fights for his life in the hospital, the team searches for Diana, a 16-year-old heart transplant patient who disappeared after cheerleading practice.

The team searches for a man who disappears after miraculously waking from a three-year coma, and uncovers a dark secret the man discovered while piecing together faint memories of life before his accident.

The FBI suspects foul play is involved in the disappearance of a lottery winner who has vanished after coming into millions.

The team tries to locate a tow truck driver who rescues a young boy and becomes a hero -- and then vanishes.

Five people with a curious connection are abducted at the same time from a coffee shop, and the team is called to investigate the unusual disappearance.

The team searches for a man whose daughter went missing years ago and wonders if his connection to a couple who are also missing a child is somehow related.

The team is called in when an up-and-coming executive at an upscale clothing company is abducted from a taxi after attending a rooftop party in Manhattan.

While searching for a missing white-collar criminal who disappears on his way to testify against a former associate, the team discovers there's more to the story.

The team investigates when the teenage son of a Secret Service agent disappears. They discover a long-festering secret that sets in motion a deadly chain of events.

After a child is kidnapped from a shopping mall, the new head of the squad, Clark Medina, shifts all resources to the abduction.

A bank manager goes missing after an argument with a mysterious man. The team tries to find the manager, and discovers a deep, dark secret which may be related to her disappearance.

The team tries to determine if a doctor's past is somehow connected to her disappearance after she vanishes from a hospital after helping a patient.

The team tries to find a missing paraplegic who was injured in a car accident two years earlier. During the investigation they discover he had been keeping a shocking secret, which may have caused his disappearance.

Jack and Samantha travel to Los Angeles to follow the trail of a man who disappears after attending his employee's funeral.

The team investigates the disappearance of a local television weatherman who goes missing after he shows up to work bleeding from his side.

The team believes they're investigating a custodial kidnapping case after a 13-year-old girl, last seen with her mother, vanishes.

The team searches for a missing bar owner who possesses a religious statue which is believed to create miracles.

The team searches for Elena's former partner, an undercover cop who goes missing after a sting.

The team searches for two women who were abducted in broad daylight, two neighbors taken from a suburban home.

The team searches for a man who is abducted while posing as a college student and discovers he has been faking his identity for years.

The team searches for a mother and her infant son who disappear after attending a self-defense class.

The team searches for a missing trial consultant and tries to narrow down the list of suspects involved with his disappearance.

During the search for a missing psychologist, the team discovers the victim's brother was imprisoned for serial rape, making them question if this past is connected to the disappearance.

As the team searches for a missing high-end Russian matchmaker, the agents find they have no shortage of suspects.

The team tries to locate the son of a billionaire who disappears after piloting a small plane that crashes in the woods.

The team searches for a missing journalist who recently graduated from reporting celebrity gossip to writing hard-hitting stories for an online magazine.

The team tries to locate a teenager who was last seen in an amateur video being psychologically tormented by an unseen abductor.

Jack grudgingly agrees to search for his daughter Hannah's boyfriend who disappears after he runs away from home in Chicago to be with her in New York.

The team searches for a man who goes missing after a late-night dive and try to zero in on who may be responsible for his disappearance.

Vivian and the team search for a blind teen and her mobility instructor who were abducted during a camping trip.

While searching for a missing nurse's aide, who disappeared from a rural road while changing a flat tire, the team discovers that this woman is actually a fugitive wanted for bombing an abortion clinic.

While searching for missing 37-year-old X-ray technician Teddy Cota, the team discovers that Teddy long believed that when he was a child, he was abducted by aliens.

Jack and the team must determine if a missing nanny is a kidnapping victim or a suspect when she and the infant in her care disappear from her employers' home.

Lynette Shaw, the physically transformed winner of the popular surgical makeover reality show "American Goddess," disappears in the midst of a publicity event.

The team searches for Colleen McGrath, a struggling, young, single mother who vanishes after leaving her 3-year-old son in his baby-sitter's care.

In a continued effort to find Colleen McGrath, a missing young mother who had recently been recruited as a drug mule, Samantha goes undercover as a woman with similar grim financial circumstances hoping to be approached by the same drug traffickers.

When a homeless woman goes missing from a shelter linked to a previous case, Jack suspects Rick Knowles -one of two identical twins--who manipulated his brother, Greg, into confessing to the murders of several other homeless women.

Jack and the team search for Peter Dusek, a wealthy, 72-year-old murder trial juror, whose disappearance could cause a mistrial.

The missing man's pregnant ex-girlfriend explains that she ended her relationship with him after he confessed that he feared the extraterrestrials would return for him and their baby.

Jack and the team search for Tara Patterson school student who was last seen by her friends at a bus stop.

While searching for convict James "Mac" MacAvoy, who disappeared during a prison yard fight, the team attempts to determine whether he's a cunning escapee or the victim of a sinister inside plot.

Jack and the team investigate the disappearance of a 12-year-old autistic boy who ran away during a class trip to a museum.

Jack and the team investigate the disappearance of Rosie Diaz, a postal employee.

Jack and the team investigate the disappearance of Chelsea Prince, a 23-year-old society girl known for her constant partying and headline-grabbing escapades.

Martin is wracked with guilt when he fails to prevent Mike, a 12-year-old boy, from being dragged into a car outside of the boy's school.

Jack and the team search for a real estate agent who went on an appointment and never returned.

Jack and the team investigate the disappearance of Stephanie, a singer in a church choir.

Vivian takes time off from work to deal with her health problems and tries to act brave before her family and colleagues.

Thirteen-year-old Daisy Thorpe goes missing in a small upstate New York town that remains shaken by the unsolved murder of the local cleric's 13-year-old daughter, Amber, seven years ago.

The team helps Danny search for his missing, estranged brother, Rafael "Rafi" Alvarez, a recovering drug addict and ex-convict who Danny grimly suspects may have lapsed into his illegal and destructive past habits.

A 71-year-old man goes missing. The team searches for the man who was last seen getting into a car with two guys.

As Vivian undergoes open-heart surgery, Jack and the team search for a missing woman who may be the innocent victim of an identity theft ring.

The team searches for a missing 5-year-old boy, Todd and his father, Randall after being tipped off by Todd's 12-year-old brother that Randall had kidnapped Todd.

Elena goes undercover as an exotic dancer at a club where a missing stripper, Cindy Peterson, worked, while Danny poses as one of her customers.

Jack and the team search for a missing 911 operator, Jessica Lawson.

The team searches for a 15-year-old prisoner, Malia Norton, who disappeared from a girls' detention center after receiving a life-threatening note.

Jack becomes fixated on using the desperate situation of Sadik Marku, the Albanian mob boss who had an ominous role in one of the team's previous cases, to unearth evidence against him.

The team searches for a family man, Aaron Gibbs, who has been emotionally haunted and financially harmed by living through and being displaced by Hurricane Katrina.

When a young woman, Katie Duncan, goes missing after a priest performs an exorcism on her, her brother asks Martin for help.

After learning that a missing man named Alex Stark lied to his girlfriend of three months about owning a cleaning service, the team wonders how he was living so luxuriously.

The team searches for social worker Eric Hayes, who disappeared after forcibly removing a 7-year-old girl from the home of her violent father and desperate mother.

The team searches for Audrey West, a young mother with one month to live.

The team searches for a 17-year-old high school basketball star, Ted Soros, who vanishes the night he scores the winning basket and secures his team's position in the state championships.

When a regional air traffic controller, Neil Rawlings, goes missing, Jack and the team learn that he had been distracted recently but was otherwise an exemplary employee.

The team searches for Barry Rosen, a competitive eating champion who vanishes after winning a $5,000 prize in a chili-eating contest.

The team searches for Abby Horton, a promising young artist who secretly photographed strangers who were experiencing intense personal moments and then later painted them.

Jack and the team search for Jason Turner, a young water plant foreman who disappears hours after his life is threatened by Earl Dooley, a longtime employee who had become enraged when Jason laid him off.

Jack and the squad interrogate a suburban tourist, Rob Darcy, who claims someone kidnapped his wife from their hotel room.

When a high-profile U.S. Senator with a wealthy father goes missing, Jack and the team are forced to do their jobs under intense scrutiny from the media and the government.

The team searches for a teenage girl who disappeared after trying to dodge the advances of an aggressive boy.

Samantha secretly searches for her missing sister, Emily, with only the aid of the local police.

The team searches for an interracial couple's six-year-old son, who was kidnapped from a farmer's market.

The team searches for a stuntman who went missing shortly after completing a dangerous, fiery stunt. They discover that he received a death threat minutes before he vanished from the film set.

After signing paperwork ordering a violent husband to vacate his home, beleaguered divorce-court judge Chris Manning disappears.

The team searches for a teenage girl who vanished during her high school prom. Witnesses reported that the girl left the festivities to rest alone in her hotel room upstairs.

The team searches for a missing 13-year-old girl whose mother fears she fell prey to a fierce neighborhood drug dealer.