Louis de Pointe du Lac lives in 1910 New Orleans as executor-in-charge of his family's fortune. When he meets the vampire Lestat, Louis' life begins to unravel in otherworldly ways. 110 years later, Louis tells his story to journalist Daniel Molloy.

Beginning his life as a vampire, Louis learns the rules of vampirism from his maker and companion Lestat. Louis discovers increasing differences between himself and Lestat. In Dubai, Louis reveals more of his modern-day vampire lifestyle to Molloy.

Louis continues his life as a businessman of Storyville. When an old friend comes to town, Louis's relationship with Lestat is tested. Louis' business intertwines with growing tensions in New Orleans, leading to a new chapter in Louis' vampire life.

Louis gives Molloy access to Claudia's diaries, which offer a fresh and contemporaneous account of the creation of the young fledgling vampire and how her Vampire guardians adjust to their new family of three.

Claudia's activities and curiosities present continued challenges for Louis and Lestat. Her actions light an explosive fuse that erupts at episode's end.

Lestat attempts to make amends with Louis. The vampire family decides to live together once more. A surprising action from Lestat leads the family to decide to leave New Orleans, once and for all. In Dubai, Molloy has a shocking realisation.

The vampire family plans to move on from New Orleans.