Bloom, Iggy and Reynolds rally around Max as he deals with the fallout from Helen's decision. Bloom gives extra space to Leyla but she's in for a surprise. Reynolds and Wilder help a terminal patient realise his dream. Iggy has a breakthrough with a challenging patient.

Max tests a new cost-saving programme that could help the hospital and its neediest patients. Wilder struggles with a patient's decision to refuse life-saving surgery. Reynolds comes to a realisation about his father's behaviours. Iggy takes the leap into online dating.

An explosion at a wedding ceremony sends a stream of partygoers into New Amsterdam. While Max and Dr. Wilder scramble to find a rare blood type to save the groom, Reynolds and Bloom treat a couple with bizarre injuries; Iggy helps a young girl out of a catatonic state.

Max mandates a personal health day for the staff and is met with surprising resistance. Reynolds is intrigued by a persuasive new member of the staff. Bloom struggles after being taken off an essential medication. Wilder is convinced by Max to get much needed surgery.

Max endeavours to save a nurse who has become the subject of a dangerous malpractice probe. Reynolds goes the extra mile to help a group of patients who are being poisoned in their own building. Bloom makes a startling admission to her sister.

Max goes on a mission to make New York safer. Iggy helps a family come to terms with their deaf child’s inability to communicate.

The New Amsterdam staff grapple with the aftermath of the recent Supreme Court decision on abortion rights. Wilder counsels a woman whose pregnancy puts her life in danger. Max endeavours to find a healthcare solution for out-of-state patients.

Max discovers a revenue-generating department at the hospital that has legal implications. Iggy discovers a janitor with otherworldly talents. Reynolds treats an inspirational patient and makes plans for his dad. Wilder's patient teaches her not to jump to conclusions.

Reynolds gets creative to help a prospective mother in need. Max takes a chance with Wilder and learns a hard truth. Bloom treats a young brother and sister in dire straits. Iggy reaches a decision about Martin.

Reynolds finds himself caught between a chance for love and an opportunity to spend precious time with his father. Bloom makes an unexpected move forward with her sister. Max helps a struggling ICU intern. Dr. Wilder is forced to make a choice.

When Helen Sharpe returns to New York, Max escapes to the wilderness on a corporate retreat with Bloom, Dr. Wilder and Iggy, but fun soon turns into catastrophe. Reynolds agrees to perform a risky surgery only to be faced with unexpected challenges outside his control.

Max and Wilder face a dilemma over approvals for a revolutionary cancer drug as Max learns a secret about his own bout with cancer. Reynolds goes the extra mile to correct a dire medical situation. Iggy tries desperately to help a woman in need.

Everyone's story reaches a surprising yet inevitable conclusion.