Tony, now separated from Carmela, takes a romantic interest in Dr. Melfi. Johnny Sack sees an opportunity for advancement when Carmine suffers a stroke, while new parolees readjust to life on the outside and Janice adjusts to married life with Bobby.

Tony throws a party for cousin Tony Blundetto who is released on parole. The FBI continues to pressure Adriana. Carmine's passing leaves the field wide open for Johnny Sack, but Little Carmine has other ideas. Tony smells a rat and leaves a clear message for the Feds.

Feech begins to overstep when he moves in on Paulie's landscaping deals. Junior wanders around his old neighbourhood searching for long-dead friends. As the hostility in New York intensifies, Johnny Sack dispatches the Leotardo brothers to send Little Carmine a message.

Tony and Carmela argue after A.J. spends a wild night in the Big Apple. Tony is forced to make a decision about Feech when he continues to overstep his bounds. Carmela finds a romantic interest in A.J.'s counsellor, while the war in New York claims its first casualties.

Tony's intense new feelings for Adriana send him back to Dr. Melfi. While Christopher is on a business trip, the crew discusses a rumour involving Adriana. Moreover, Tony may have skin cancer.

Tony B. makes an effort to go straight as he prepares to open his own massage studio, but a mysterious bag of cash tempts him back to his old habits. A.J. moves back in with his mother after a fight with Tony, while Carmela pursues her liaison with her son's counsellor.

Tony pays a visit to his father's gravesite and meets a woman who claims to be his father's mistress. Christopher takes a friend from rehab to the executive poker game, but he soon goes from sponsor to strong-arm man when his friend can't pay his debts.

Carmela invites Tony to participate in her father's birthday party, and the evening ends in a romantic encounter. Little Carmine's men try to recruit Tony B. for a retaliation against Johnny Sack's crew. Tony B. is reluctant, but his boredom soon gets the better of him.

Rumours about Tony B's involvement in the Joey Peeps hit reach Johnny Sack, who considers going to war with Little Carmine. Carmela learns Tony has made it impossible for her to hire a divorce lawyer. Tony explores his guilt over his cousin's incarceration with Melfi.

Janice attacks a mother during her stepdaughter's soccer game and is forced to attend anger management classes. Tony must deal with his own anger as Johnny Sack launches payback against the Sopranos. Christopher and Tony B. dispose of several incriminating corpses.

Tony escapes to the Plaza Hotel for a night of rest and relaxation, but his dreams are haunted by past faces. Another casualty falls in the war between Johnny Sack and Little Carmine, and Tony B. heads to New York for revenge.

The FBI finds evidence that they use as leverage against Adriana. Adriana relents and tries to persuade Christopher to go into witness protection with her. Tony and Carmela meet over lunch and work toward a reconciliation. Johnny Sack delivers a stern ultimatum to Tony.

Tony faces pressure from his crew to give up his cousin to Johnny Sack. Tony does some soul-searching on Melfi's couch and finally decides on a course of action. Tony meets with Johnny Sack to restore peace between Jersey and New York but the Feds play a surprise card.